PCRD DENFREE
Porteur : Éric Daudé
Dates : 2012-2016
Vector-borne diseases are a major public health burden with a high potential for epidemic outbreaks, particularly in regard to climate change and the increasing urbanization worldwide. The mosquito Aedes aegypti is one of the main vectors of such diseases that include Dengue, Zika and Chikungunya. Pending effective vaccines, the presence of this mosquito species, which is perfectly adapted to urban environments, needs to be monitored and controlled. This includes the production of geographic databases and dynamic models contributing to the assessment of vector and epidemic risks at different scales, especially the micro-localization of urban spaces. These risks arise from an articulation of environmental, biological and social factors that we proposed to considere as a “complex pathogenic system”. In this context we have developed a vector-borne disease simulator to explore two important issues: the reproductive and dispersal capacity of Aedes aegypti according to local socio-environmental contexts and the role of human mobility in the dispersion of viruses transmitted by the mosquito at intra-urban scales. Three sub-models have been developped and explored separately in order to calibrate them: MOMA, MODE and MOMOS, respectively model of mosquito, of environment and host.
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